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If you have or have had cancer, talk with daily your healthcare provider about whether you should use provera. Report any unusual vaginal bleeding right away. What can I do to lower my chances of a serious side effect with provera? In both studies, MPA was quantified in serum using a validated gas chromatography -mass spectrometry (GC-MS) method. Ovarian Cancer The WHI estrogen plus progestin substudy reported a statistically non-significant increased risk of ovarian cancer. Before you take Provera, tell your healthcare provider if you: have any other medical problems Your healthcare provider may need to check you more carefully if you have certain conditions such as asthma (wheezing epilepsy (seizures diabetes, migraine, daily endometriosis. Should a stroke occur or be suspected, estrogen plus progestin therapy should be discontinued immediately. Number of Women with Endometrial Hyperplasia at 1 Year CEE MPA CEE * (n283) MPA 5 mg (n277) MPA 10 mg (n272) Cystic hyperplasia daily 55 provera (19) 3 (1) 0 Adenomatous hyperplasia without atypia 2 (1) 0 0 Women's Health Initiative. Are going to have surgery or will be on bed provera rest Your healthcare provider will let you know if you need to stop taking Provera. Do not use if this medicine you are pregnant. Tell your healthcare provider about all the medicines you take including prescription and nonprescription medicines, vitamins, and herbal supplements. Pregnancy Provera should not be used during pregnancy. The lowest effective dose of provera has not been determined. Provera is a medicine that contains medroxyprogesterone acetate, a progestin hormone. Clinical studies and, warnings, Probable Dementia and, precautions, Geriatric Use. What are the ingredients in Provera? Long-term use of medroxyprogesterone may increase your risk of breast cancer, heart attack, stroke, or blood clot. the, women's Health Initiative wHI ) estrogen plus progestin substudy reported an increased risk of deep vein daily thrombosis dVT pulmonary embolism (PE stroke and myocardial infarction (MI) in postmenopausal women (50 to 79 years daily of age) during.6 years of treatment. Probable Dementia In the whims estrogen plus progestin ancillary study of WHI, a population of 4,532 postmenopausal women aged 65 to 79 years was randomized to daily CE (0.625 mg) plus MPA (2.5 mg) or placebo. To make sure medroxyprogesterone is safe for you, tell your doctor if you have: heart disease, congestive heart failure, recent stroke or heart attack high blood pressure; provera high cholesterol or triglycerides; low levels of calcium in your blood; severe pelvic pain;. Talk with your healthcare provider regularly about whether you should continue taking provera. Overgrowth of the lining of the uterus: When used in combination with oral conjugated estrogens in postmenopausal women with a uterus, Provera may be given daily in doses ranging from 5 or 10 mg daily for 12 to 14 straight days per month. Taking a progestin such as Provera in combination with an estrogen reduces the risk for endometrial cancer by preventing an overgrowth of the uterus. (See warnings, Probable Dementia and precautions, Geriatric Use ). Exacerbation of other conditions Estrogen plus progestin therapy may cause an exacerbation of asthma, diabetes mellitus, epilepsy, migraine, porphyria, systemic lupus erythematosus, and hepatic hemangiomas and should be used with caution in women with these conditions. Talk to your doctor about your specific risks and benefits of taking this medicine, especially if you smoke or are overweight. 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