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Adverse Reactions Diovan has been evaluated for safety in more than 4000 patients, including over 400 treated for over 6 months, and more than 160 for over 1 year. Diovan should not be given to a child younger professional than 6 years old. The Diovan dose may need to be increased if the diovan suspension is diovan replaced by a tablet. Read all patient information, medication guides, and instruction sheets provided to you. Following intravenous administration, plasma clearance of valsartan is about 2 L/h and its renal clearance.62 L/h (about 30 of total clearance). No dosage adjustment is necessary (see dosage AND administration). Metabolism and Elimination, valsartan, when administered as an oral solution, is primarily recovered in feces (about 83 of dose) and urine (about 13 of dose). Call your doctor if you are sick with professional vomiting or diovan diarrhea, or professional if you are sweating more than usual. Keep using this medicine as directed, even if you feel professional well. This condition should be corrected prior to administration of Diovan, or the treatment should start under close diovan medical supervision. The inhibitory or induction potential of valsartan on diovan CYP 450 is also unknown. Headache, dizziness, upper respiratory infection, cough, diarrhea, rhinitis, sinusitis, nausea, pharyngitis, edema, and arthralgia occurred at a more than 1 rate but at about the same incidence in placebo and valsartan patients. During repeated dosing, the reduction in blood pressure with any dose is substantially present within 2 weeks, and maximal reduction is generally attained after 4 weeks. Common Diovan side effects may include: headache, dizziness, tired feeling; flu symptoms; stomach pain, diarrhea; back pain, joint pain; or cough. In multiple-dose studies in hypertensive patients, valsartan had no notable effects on total cholesterol, fasting triglycerides, fasting serum glucose, or uric acid. Your blood pressure will need to be checked often. Administration of valsartan to patients with essential hypertension results in a significant reduction of sitting, supine, and standing systolic and diastolic blood pressure, usually with little or no orthostatic change. Skip the missed dose if it diovan is almost time for your next scheduled diovan dose. One valsartan patient discontinued treatment for microcytic anemia. Dispense in tight container (USP). Take the missed dose as soon as you remember. Other adverse experiences that occurred in controlled clinical trials of patients treated with Diovan (.2 of valsartan patients) are listed below. You may have very low blood pressure while taking valsartan. To make sure Diovan is safe for you, tell your doctor if you have: kidney disease (or if you are on dialysis liver disease; a heart condition, other than one being treated with valsartan; if you are. Body as a Whole: Allergic reaction and asthenia Cardiovascular: Palpitations Dermatologic: Pruritus and rash Digestive: Constipation, dry mouth, dyspepsia, and flatulence Musculoskeletal: Back pain, muscle cramps, and myalgia Neurologic and Psychiatric: Anxiety, insomnia, paresthesia, and somnolence Respiratory: Dyspnea Special Senses: Vertigo. Take the medicine at the same time each day. Further information Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Diovan only for the indication prescribed. Usual Pediatric Dose for Hypertension: 6 to 16 years: Initial dose:.3 mg/kg once diovan daily (up to 40 mg) Maintenance dose: up.7 mg/kg (up to 160 mg) once daily titrated according to patient response If the calculated. Diovan is sometimes given together with other blood pressure medications. Care should be exercised in patients with liver disease (see dosage AND administration). Drug Interactions No clinically significant pharmacokinetic interactions were observed when valsartan was coadministered with amlodipine, professional atenolol, cimetidine, digoxin, furosemide, glyburide, hydrochlorothiazide, or indomethacin. Valsartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Liver function tests: Occasional elevations (greater than 150) of liver chemistries occurred in Diovan-treated patients. These doses in mice and rats are about.6 and 6 times, respectively, the maximum recommended human dose on a mg/m2 basis. In multiple-dose studies in hypertensive patients with stable renal insufficiency and patients with renovascular hypertension, valsartan had no clinically significant effects on glomerular filtration rate, filtration fraction, creatinine clearance, or renal plasma flow. Medical Disclaimer Next Side Effects Add to My Med List More about Diovan (valsartan) Consumer resources Other brands: Prexxartan Professional resources Other Formulations Related treatment guides. Valsartan shows bi-exponential decay kinetics following intravenous administration, with an average elimination half-life of about 6 hours. If oliguria diovan occurs, attention should be directed toward support of blood pressure and renal perfusion. Hepatic Insufficiency: On average, patients with mild-to-moderate chronic liver disease have twice the exposure (measured by AUC values) to valsartan of healthy volunteers (matched by age, sex and weight). Adverse experiences have generally been mild and transient in nature and have only infrequently required discontinuation of therapy. If oligohydramnios is observed, valsartan should be discontinued unless it is considered life-saving for the mother.
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