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Texas already had the most restrictive abortion laws in how much does renova cream cost the U.S.—and they just got tougher. On Wednesday, a new law took effect that adds penalties of jail time and a fine of up to $10,000 for anyone who prescribes pills for medication abortions through telehealth or the mail. Texas bans all abortions after cardiac activity can be detected in the how much does renova cream cost embryo, which typically occurs about six weeks into pregnancy—often before people realize they’re pregnant. Medication abortions via telehealth or mail were already illegal in Texas, and the new criminal penalties took effect on the day the Supreme Court heard arguments in a Mississippi case that ultimately could overturn Roe v.

Wade, the landmark 1973 ruling that established a constitutional right to abortion. In contrast to a surgical abortion, which usually takes place in a clinic, a medication abortion involves two pills, taken 48 hours apart, how much does renova cream cost that manipulate the hormones to end a pregnancy. Many people prefer this process early in a pregnancy because the pills can be taken at home. The Food and Drug Administration approved the drugs in 2000, and the procedure is effective up to 10 weeks into a pregnancy.

Texas is not the only how much does renova cream cost state that restricts medication abortion and telehealth. This year alone, five other states have passed laws against sending abortion pills through the mail, said Elizabeth Nash, a state policy analyst with the Guttmacher Institute. €œIt’s a squeeze play on abortion,” she said. Nash said this crackdown is partially a response to the renova, how much does renova cream cost which propelled interest in medication abortions.

€œWe saw the increase and, really, sort of the coming out of telehealth as part of medical practice,” she said. Texas’ new law, known as SB 4, also narrows the legal window for medication abortion to the first seven weeks of pregnancy. State legislators passed this how much does renova cream cost new law on Sept. 17 during a special session—more than two weeks after the other abortion law, often called the “six-week ban,” took effect on Sept.

1. Attempts to halt that how much does renova cream cost law as groups challenge it in court have failed. €œWe already have the most extreme abortion ban in the U.S. And yet our legislature made it a priority to add this additional abortion restriction,” said Sarah Wheat, chief external affairs officer with Planned Parenthood of Greater Texas.

Because of the six-week ban, the new limits on medication abortions how much does renova cream cost won’t have an immediate impact. €œMost people at this stage of a pregnancy are already banned from accessing abortion in Texas,” Wheat said. But the new law could significantly affect future access to abortion. By criminalizing how much does renova cream cost the use of telehealth and mail-order prescriptions to acquire abortion pills, the state seeks to forestall a possible workaround to the shrinking number of reproductive health clinics in Texas.

Already, many Texans live hundreds of miles from the nearest clinic offering abortion services. Advocates have promoted the use of telehealth for medication abortions in places where clinics are few and far between, and some states experimented with greater telehealth flexibility—including for abortion pills—during the renova shutdowns. The new law “is creating additional fear and additional stigma for people how much does renova cream cost who may be seeking access to medication abortion,” Wheat said. Anti-abortion groups in Texas hailed SB 4 as a victory—an important second step, after the six-week ban, in their efforts to curtail all access to the procedure in the state.

John Seago, legislative director for Texas Right to Life, said his group wanted to ensure that law enforcement officials could prosecute people who skirt the state’s strict limits by administering medication abortions. €œThis piece is really important for this period but also moving into how much does renova cream cost the future, when we see even after [Roe v. Wade] we have organizations and individuals advertising that they will mail abortion-inducing drugs,” he said. Nash of the Guttmacher Institute said that in some states it has become easier for people to obtain medication abortions through telehealth services.

Seago said he wants to make sure that how much does renova cream cost doesn’t happen in Texas. €œThis is going to be a future public policy issue around abortion, no matter what happens to Roe v. Wade,” he said. So far, no lawsuit how much does renova cream cost has challenged Texas’ law restricting access to abortion pills.

Mounting a legal challenge to halt the law is complicated because Texans already are effectively prohibited from all abortions after six weeks. Finding legal standing to sue would likely be difficult for any Texas plaintiff. Ultimately, Wheat said, Texas’ latest law is a sign how much does renova cream cost of what could happen elsewhere. She said it shows there is no end to efforts aimed at making abortions harder to get.

€œTake note of Texas, because what you see is that our politicians, they do not quit, and they can find endless ways to add fear, intimidation and restrictions,” Wheat said. This story is part of a partnership how much does renova cream cost that includes KUT, NPR and KHN. KHN (Kaiser Health News) is a national newsroom that produces in-depth journalism about health issues. Together with Policy Analysis and Polling, KHN is one of the three major operating programs at KFF (Kaiser Family Foundation).

KFF is an endowed nonprofit organization providing information on health issues to the nation.The vast, turbulent Southern Ocean circling Antarctica has an how much does renova cream cost unexpected claim to fame. It’s one of the planet’s most important natural climate tools. Like all the world’s oceans, it draws carbon dioxide out of the atmosphere and into the water. But the how much does renova cream cost Southern Ocean is a special case.

It stores up more carbon than any other body of water on Earth. That could change, though. Some scientists believe that as the Antarctic climate how much does renova cream cost changes—complete with melting sea ice, shifting wind patterns and changing ocean currents—the Southern Ocean might soak up less carbon. That’s a big concern for the climate.

The less carbon sinks into the sea, the more stays in the atmosphere, where it contributes to increased global warming. Keeping an eye on the Southern Ocean is vital to making accurate predictions of how quickly the world how much does renova cream cost may warm in the future. It’s no easy job, though. The Southern Ocean is notoriously difficult to monitor—the region is icy and stormy and often difficult to access by ship or by plane.

Scientists have been able to keep tabs on it through a combination of methods, from floating instruments in the how much does renova cream cost ocean to aircraft flying overhead. Another complication. Not all the studies agree with one another about how much carbon, exactly, the ocean is sucking up. There are how much does renova cream cost still a lot of questions about whether it’s weakening yet, or if it will in the future, and what that means for the planet.

But one of the newest studies contains some reasons for optimism. Published Thursday in the journal Science, the study finds that the Southern Ocean is still a strong carbon sink. It estimates the region how much does renova cream cost is soaking up more than half a billion metric tons of carbon from the air each year. (By comparison, human activities release about 10 billion metric tons of carbon into the atmosphere each year.) The study pulls data on atmospheric carbon dioxide collected by research aircraft flying over the ocean between 2009 and 2018.

Most of how much does renova cream cost that carbon is getting absorbed over the summer. During the winter, there’s not much carbon sinking in—and there may even be a little bit seeping back out. Still, the news looks good overall. The study suggests the Southern how much does renova cream cost Ocean is still doing its job, soaking up a hefty chunk of carbon from the atmosphere each year.

An exceptional solution The latest findings, however, reignite past worries about how much scientists really know about what’s happening at the bottom of the world. Previous studies have produced mixed results about how much carbon the Southern Ocean is storing away and whether that’s changing over time. They’ve sometimes disagreed with one how much does renova cream cost another. Or they’ve suggested the carbon sink may fluctuate over time, sometimes weakening and sometimes strengthening.

A 2015 study—, for instance, found that the Southern Ocean carbon sink was weakening during the 1990s—but it began strengthening again around 2002. The study suggested that the ocean may swing naturally back and forth in this way, shifting every how much does renova cream cost decade or two. The study relied on surface measurements taken by passing ships. But a 2018 study found that the Southern Ocean may be taking up significantly less carbon than previous ship-based measurements may have indicated.

The research, which relied on a network of floating sensors in the ocean, suggested that one key area in the Southern Ocean is releasing large volumes of carbon dioxide back into the atmosphere during the winter in a process how much does renova cream cost known as “outgassing.” It estimated that as much as a third of a billion tons more carbon may be escaping than previously estimated. The Southern Ocean is still absorbing carbon on the whole, the study noted. It’s just taking up much less than scientists thought. Then again, a study how much does renova cream cost published earlier this year found that the winter outgassing is not as strong as the 2018 research would suggest.

That study relied on measurements collected by seafaring drones. The new study from last week also found there may be some winter outgassing—but not very much. The patterns over the course of the year are similar to some how much does renova cream cost of the previous studies. Carbon uptake in the summer and some carbon release in the winter.

It’s just the amount of carbon passing between the sea and the sky, especially in the winter, that’s different. It’s not completely clear yet what’s causing the discrepancies how much does renova cream cost. Measurements taken from floats in the ocean can be difficult to interpret, said Matthew Long, a scientist at the National Center for Atmospheric Research and lead author of the new study. Different regions of the ocean absorb or release different amounts of carbon—an instrument in one place might not collect the same results as an instrument in another.

€œUnless you have a lot of data, it can be very challenging to develop an accurate picture from how much does renova cream cost surface observations,” he said. Aircraft observations, on the other hand, give a comparatively precise picture of how much carbon is in the atmosphere at any given time. The results of the new study may give scientists a reference point for other studies and help them figure out why other kinds of methods, like floats or drones, don’t always agree. More aircraft campaigns also could help scientists keep a better eye on how much does renova cream cost the Southern Ocean in the future.

Even if the region is still a strong carbon sink today, scientists warn its status could change in the future. Some studies suggest that certain aspects of future climate change—such as warming waters, melting sea ice or shifting wind patterns—may cause the Southern Ocean to absorb less carbon dioxide or to spew more of it back out in the atmosphere. Increasing aircraft how much does renova cream cost observations may also be useful in other places around the world. Oceans, lakes, wetlands, forests, grasslands and other natural landscapes all over the world are vital parts of the natural carbon cycle.

Many of them are still absorbing carbon dioxide from the atmosphere—but as the climate continues to warm, and other human disturbances take their toll, some of these landscapes are soaking up less carbon or even pouring out more than they take in. Keeping track of these fluxes is an important part of the world’s global carbon accounting, helping scientists make better predictions about how quickly the world how much does renova cream cost will warm in the future. Scientists sometimes have difficulty accounting for where, exactly, all the world’s carbon emissions are ending up. €œThe really important thing that we’ve demonstrated here is aircraft observations have the capacity to resolve uncertainty in the carbon cycle,” Long said.

€œWe have a hypothesis that an how much does renova cream cost investment in a global-scale, regular aircraft observing program would be an exceptional way to address that problem.” Reprinted from E&E News with permission from POLITICO, LLC. Copyright 2021. E&E News provides essential news for energy and environment professionals.Every evening, after twilight gives way to dark, hordes of marine creatures—from tiny zooplankton to hulking sharks—rise from the deep to spend the night near the surface. They revel in the upper waters, feeding and mating, before retreating back down before dawn how much does renova cream cost.

Known as the diel vertical migration, this mass movement is often heralded as the largest synchronous migration on Earth. As the planet spins on its axis and patches of ocean turn toward or away from the sun’s light, it happens in continual flux around the world. The migration was first documented in the early 1800s, when naturalist how much does renova cream cost Georges Cuvier noted that plankton called daphnia—water fleas—were disappearing and reappearing in a daily cycle in a shallow freshwater lake. Then, during World War II, came the discovery of the “deep scattering layer”.

A zone in the oceans that unexpectedly deflected pings of Navy sonar and mysteriously disappeared each night, like a phantom seabed. Scripps Institution how much does renova cream cost of Oceanography scientist Martin Johnson proposed an explanation. The deep scattering layer could be marine animals migrating up to the surface. In June of 1945, he tested the idea on an overnight excursion in the waters off Point Loma, California.

The zooplankton, jellyfish and various crustaceans he caught in a series of 14 how much does renova cream cost hauls established that the moving layer was indeed made up of living creatures undertaking an evening migration. Since then, scientists have spotted this regular commute in pretty much every body of water they’ve looked at. €œIt’s universal across habitats,” whether marine, freshwater or brackish shores, says Kanchana Bandara, a marine scientist at the Arctic University of Norway. €œIt’s universal across geographic locations, from the tropics to the poles, and it’s universal across the taxonomic groups, from little zooplankton or phytoplankton to large whales and sharks.” But despite its how much does renova cream cost pervasiveness, puzzles remain.

Research suggests that changes in light trigger the evening trek, so it’s unclear how animals in waters around the Earth’s poles—where there are months when sunlight is constant or completely absent—know when it’s time to migrate. Researchers are working to understand this, as well as nailing down when various creatures make their journeys—and why some choose not to travel at all. Understanding these nuances is important, scientists say, because the diel vertical migration serves as a giant conveyor belt transporting how much does renova cream cost carbon that is nibbled in surface waters down into the deep—carbon that might otherwise just linger at the ocean surface or return to the atmosphere. It’s a costly habit.

Estimates suggest that over a year, the collective energy spent commuting by zooplankton alone is equal to about a year’s worth of energy consumption in the United States. €œThat’s an unimaginable amount of energy” Bandara says how much does renova cream cost. Diel migration by the light of the moon There’s a consensus among scientists that for many creatures, including zooplankton like daphnia, the migration helps them avoid being eaten. Deeper, dark waters provide refuge from the eyes of predators during the day.

Visits to the surface, where food lies in greater abundance, how much does renova cream cost are most safely done under cover of night. Scientists also agree that changing light intensity is the primary environmental cue for migrators, says Heather Bracken-Grissom, a marine biologist at Florida International University. When light starts to fade, that can trigger the ascent to the surface. But that’s not the whole how much does renova cream cost story.

Scientists had long assumed, under the light-following model, that daily migrations would cease during the Arctic winters, when there are months without daylight. But in 2008, researchers reported that zooplankton were, indeed, partaking of an how much does renova cream cost evening migration in Arctic waters off Svalbard during the long polar night. More recent research has established that this pattern is widespread—and can be driven by moonlight. Reporting in 2016, a team of scientists from Norway and Great Britain surveyed waters around the Arctic in the months before and after the winter solstice, when the sun is always below the horizon.

Using hydroacoustic how much does renova cream cost sampling techniques, the team discovered that the tiny marine creatures had shifted their migrations, syncing them with the light of the moon rather than that of the sun. And in addition to the daily cycle there was a monthly signal. The animals were regularly moving to deeper waters during the bright light of the full moon. Scientists are also learning more about the supreme how much does renova cream cost sensitivity of zooplankton to changes in light.

Working in the northern Pacific Ocean, a team used sonar-like acoustic sampling to detect the daily movement of critters including copepods, ostracods, salps and krill. The recorded weather was consistently overcast, gray and drizzly, but the zooplankton could still detect variations in the thickness of cloud cover and adjust their depth, the team reported in PNAS in August. A difference in brightness of only 10 to 20 percent was enough to prompt how much does renova cream cost mini-migrations of 50 feet—no small trek for the tiny animals. The constant daylight of a polar summer also doesn’t seem to stop zooplankton from their nightly pilgrimage.

Over several years in the waters off the western Antarctic coast, researchers used specialized nets that collected samples at specific depths. Examining the contents, the team found that the critters how much does renova cream cost kept up their migration throughout the constant light of summer, although for some, the commutes were shorter when the days were longer. The fact that the tiny marine animals conserved their daily cycle even without the dark suggests that some other signal triggers their migration, either independently or in combination with light—perhaps an internal circadian clock, says study coauthor Patricia Thibodeau, a plankton ecologist at the University of Rhode Island. Through genetic studies and lab and field experiments, scientists recently established that such a clock does guide the daily cycles of some migrators, including the copepod Calanus finmarchicus and the Antarctic krill Euphausia superba.

The research suggests that since the stakes are so how much does renova cream cost high—migrate or be eaten—evolution favored development of an internal circadian cycle for diel migration, as a backup to reliance on environmental cues. Predators may influence the decision to migrate The high stakes around daily migration also seems to shape how creatures behave during their commute. Research has found that migrators off Santa Catalina Island in California tend to stick together in coherent groups or schools as they travel, which may reduce the risk of being eaten. Larger, more conspicuous animals such as fish migrate later—roughly how much does renova cream cost 80 minutes after sunset—than smaller, less visible animals, which begin their migration up to 20 minutes before sunset.

The presence of predators also prompts some migrators to delay their trek. When squid-eating Risso’s dolphins, for example, were in the area, researchers observed that squid waited in deeper waters, postponing their journey by roughly 40 minutes. And some individuals, on how much does renova cream cost some days, appear to skip the commute entirely. Researchers suspect that they might not always be hungry enough to feel the journey is worth the risk.

This idea, known as the “hunger/satiation hypothesis,” posits that individuals in a population are motivated by their own hunger levels. A team including Nova Southeastern University marine ecologist Tracey Sutton put this theory to the how much does renova cream cost test, taking advantage of trawl surveys in the Gulf of Mexico following the Deepwater Horizon oil spill. Over a span of seven years, automated net systems collected specimens from sampling stations across the gulf, in both deep and surface waters. Of those, 588 critters were then sent to labs, so the team could “crack open their stomachs and see what they eat,” says Sutton, who coauthored an overview of deep ocean food webs in the 2017 Annual Review of Marine Science.

The scientists found that those that didn’t migrate still had food in their stomachs, suggesting they chose how much does renova cream cost not to make the trek because they were still satiated from the previous night. And migratory individuals were more likely to have emptier stomachs. But exceptions remained—one fish and two crustacean species didn’t follow that pattern, suggesting that individuals within a population “choose” whether or not to migrate, the researchers reported in February in Frontiers in Marine Science. The species of fish whose migration patterns didn’t align also had shallower migrations, and may have a faster how much does renova cream cost metabolism than other species—variables that may interplay, Sutton says, making it difficult to draw any universal conclusions.

Hunger, light, genetics and more—scientists are continuing to probe these and other factors that affect this great commute, including salinity, temperature and exposure to UV light. Studying these variables, along with which animals are moving when and who is eating who, is key to understanding the Earth’s carbon cycle, says Sutton, and how this massive commute helps sequester it over time. The migration, he says, “is more or less how much does renova cream cost everything, if you’re really tracking carbon.” 10.1146/knowable-110421-1 This article originally appeared in Knowable Magazine, an independent journalistic endeavor from Annual Reviews. Sign up for the newsletter.Imagine you have a jigsaw puzzle with 10,000 pieces but no picture on a box.

In fact, you don’t even have the box—it was destroyed nearly 2,000 years ago. These puzzle pieces are fragments of frescoes in the ancient how much does renova cream cost Roman city of Pompeii that were leveled or buried by the eruption of Mount Vesuvius in A.D. 79. Some pieces are missing, others are broken.

And instead how much does renova cream cost of being precisely-cut shapes designed to neatly interlock, they’re damaged, irregular fragments. How would you solve this puzzle?. Scientists at the Italian Institute of Technology (IIT) have a plan. Send in how much does renova cream cost the robot.

Their project—dubbed RePAIR (Reconstructing the Past. Artificial Intelligence and Robotics meet Cultural Heritage)—melds robotics, AI and archaeology in an attempt to reconstruct architectural features of Pompeii that would otherwise remain incomplete, because they’re either too complex or would require impossible amounts of human labor and time. Over the next how much does renova cream cost several months, the IIT researchers and their collaborators at a handful of international universities will build, train, test and deploy a robot to piece together ruined wall frescoes in two buildings. In the first building, they know what the frescoes should look like because they were intact until recently.

The investigators have no idea what the frescoes in the second building depict. Its fragments how much does renova cream cost have lain in a storage room for decades waiting for someone—or something—to put them back together. RePAIR is experimental and might fail, admits Arianna Traviglia, director of the Venice-based IIT Center for Cultural Heritage and Technology and a principal investigator of the project. It’s funded by a 3.5-million-euro grant from a European Commission fund that supports risky projects aimed at “radically new future technologies.” If the project succeeds, the technology can be used to reconstruct a variety of fragmented cultural artifacts whose restoration has remained “out of human reach,” says project coordinator Marcello Pelillo, a professor of computer science and artificial intelligence at the University of Venice.

€œLet’s hope we how much does renova cream cost are successful, because it’s never been tried before,” Traviglia laughs. €œIt’s really craziness at the highest level.” THE BRAINS RePAIR’s as-yet-unnamed robot must have a combination of brains, strength and a sensitive touch. The brains will come from a mix of high-tech computer vision to scan the fresco puzzle pieces, machine-learning algorithms to solve the puzzles and human expertise to guide the AI. €œWe think that using an AI-based system will not be enough,” says Pelillo, whose group is developing the puzzle-solving AI in conjunction with how much does renova cream cost a team at Ben Gurion University of the Negev.

That’s why they’ll get guidance from archaeologists and art historians about the different styles of frescoes found in Pompeii. In Pompeii, the researchers are in the process of manually digitizing every fresco fragment in the two test sites to create a digital database for the RePAIR robot. Once the whole how much does renova cream cost system is fully operational, though, “we’ll have the robot doing the scanning process itself,” Pelillo says. When robots can handle routine digitization, humans are free to handle more complex tasks.

Graduate students can’t scan 24/7 without food, water or sleep—but a robot can. €œThe idea is to work towards automating as much as possible this quite time-consuming and also boring activity of digitizing cultural heritage,” Traviglia says how much does renova cream cost. Researchers are training soft robotic hands to carefully manipulate ancient fresco fragments found at Pompeii. Credit.

IT-Istituto Italiano di Tecnologia how much does renova cream cost. The humanoid robot is composed of a torso and arms being developed by Nikolaos Tsagarakis and his colleagues at the Humanoid &. Human Centered Mechatronics lab at IIT in Genoa. With arms how much does renova cream cost 80 to 100 centimeters long and a weight of 25 to 30 kilograms, the robot will be about the same size as the upper body of an average person.

Its design is based in part on earlier “compliant humanoid” robots Tsargarakis’s lab developed for use in disaster sites, including WALK-MAN, which in 2016 explored a damaged building in the Italian village of Amatrice, where an earthquake had killed nearly 300 people. Hands will attach to how much does renova cream cost the arms through sockets at the wrist. They’re being designed in the lab of Antonio Bicchi, a senior scientist at IIT in Genoa and the chair of robotics at the University of Pisa, who has developed robotic hands for use in industry and as prosthetics. At Pompeii, the soft robotic hands will need to grasp, move and orient fragments of varying sizes and weights with extreme care—and gather information about them in the process.

These hands how much does renova cream cost are like soft but smart gloves that are embedded with tactile, kinesthetic and position sensors. Ideally, Bicchi says, people will be able to wear them over their own hands one day to gather additional data that human hands can’t obtain on their own. The researchers are still working on the final design of the robot (an alternate design forgoes the torso and simply suspends the arms from a metal frame), but it will probably be mounted on a slider on a workbench so that it can easily move from one end of the workspace to the other. Once installed, the soft hands will grasp the pieces, 3-D-scan them, and send how much does renova cream cost the data to the puzzling-solving AI, which will attempt to find virtual matches.

Once it has a solution, the AI sends the data to the hands, which assemble the pieces. THE PUZZLE SITES The first fresco puzzle the RePAIR scientists will attempt to solve with the new robot is a part of the Schola Armaturarum, the headquarters of a military-style association located on Via dell’Abbondanza, Pompeii’s main street, where members planned military activities and gladiator battles. Unearthed in 1915, its large hall was how much does renova cream cost decorated with representations of trophies and weapons and lined with wooden cabinets that may have displayed armor and trophies. It survived both the volcanic eruption and a direct hit from an Allied bomb in 1943, but parts of it collapsed in 2010 after heavy rains poured on Pompeii, including the wall frescoes the researchers will attempt to reconstruct.

Because they know what the frescoes originally looked like, it’s a good place to test out the robot’s capabilities. If the robot succeeds with the Schola Armaturarum frescoes, the team will next attempt how much does renova cream cost to solve the fresco puzzles found in two collapsed rooms in the House of the Painters at Work. This building is so named because artisans were in the process of painting frescoes there when Vesuvius erupted. Archaeologists unearthed their buckets and brushes, as well as the faint outlines of frescoes awaiting color, shading and detail that never came.

Parts of the building were destroyed then, how much does renova cream cost and it was also badly damaged by World War II bombings. Because each crumbled wall represents one fresco puzzle, and there are no reference images to work from, this site poses a far larger challenge. €œImagine you have five different puzzles—one with the Eiffel Tower, the other one with the Coliseum, etcetera,” Pelillo says. €œYou open the boxes, and you just mix all how much does renova cream cost the pieces.

And then you are asked to solve the five puzzles. This is actually what we are going to do.” They RePAIR scientists aim to install the robot in Pompeii (the exact location is still being decided) by spring or summer 2022. They have how much does renova cream cost some time to experiment. Their grant supports the project through 2025.

The researchers see a world of possibility ahead for the robot. Museums and universities across the globe hold fragmented remains in their collections, many of them ignored how much does renova cream cost for decades. €œWe hope that if we succeed with this project, we will be able to offer a technology which will allow many museums around the world to reconstruct large-scale broken frescoes or similar artifacts,” Pelillo says. €œWe are focusing mainly on frescoes, but that’s just the case study.

If we succeed, we think we can export this technology to other artifacts or even, for example, to papyri.”1971 How Birds Breathe “A bird’s respiratory system can deliver enough oxygen how much does renova cream cost for the animal to fly at altitude. How do the birds do it?. The bones of birds contain air. This is true not only of the larger bones but also often of how much does renova cream cost the smaller ones and of the skull bones.

Birds have two lungs that are connected to the outside by the trachea, but in addition they are connected to several large, thin-walled air sacs that fill much of the chest and the abdominal cavity. The sacs are connected to the air spaces in the bones. In this way it becomes apparent that the blood, as it is about to leave how much does renova cream cost the lungs, can take up oxygen from air that has the highest oxygen concentration available anywhere in the system.” 1921 Needed. Teachers Who Experiment “What must America do to establish itself as the leader among nations for world trade?.

The principal essential is a body of trained investigators. Nowadays what most how much does renova cream cost of us are doing depends upon some phenomenon or property of matter unknown a century ago, which has now become a pillar of civilization. We have splendid laboratories. We have a wealth of materials.

We have abundant money how much does renova cream cost. But we need more college professors who are not content to give their pupils merely the results of scientists of the past, but who are themselves experimenting to learn new scientific truths, and who encourage their pupils to experiment.—W. R. Whitney, Director, General Electric Research Laboratory” Smoke, Not Fire “A new form of fire alarm how much does renova cream cost has been invented in England.

It depends upon the presence of smoke and is not affected by temperature changes, which usually are the chief factors in the operation of most fire alarms. The smoke detector consists of a metal cylinder some eight inches long and two inches in diameter, open at each end, so that air can circulate freely, and containing two rectangular metallic capsules, one of which is considerably larger than the other. The smoke on the capsules causes one to bend more than the how much does renova cream cost other, completing an electrical circuit, and a large electric bell or other alarm signal may be operated. The advantage is that its action is more rapid and reliable.

In many fires dense smoke would be produced before any material rise in temperature occurred.” 1871 Also Needed. Practical Education “The custom of learning everything by rote, and reciting like a how much does renova cream cost parrot, has become so embedded in our system of education that it seems almost impossible to find any explosive sufficiently active to blow it up. It is probable that we must look to the West. At the University of Iowa, instead of teaching physics, chemistry, geology and astronomy by oral recitations and unillustrated lectures, they have established laboratories and workshops where practical things can be practically learned.

The trustees have resolved to how much does renova cream cost place the elements of physical science at the very beginning of the course. They do not propose to wait until the pupil, by droning over dry facts and abstract principles, has acquired a disgust for every branch of knowledge. They think it wiser to pursue the natural method, and begin when the mind is anxiously inquiring into the cause of things.” Dehydrated Meat “At the meeting of the Lyceum of Natural History, Dr. H.

Endemann gave an account of a process invented by himself. About 100 pounds of meat are placed in a suitable chimney, and air, heated to 140 degrees Fahrenheit, is drawn by an exhauster through it until it is entirely dry. The meat is subsequently ground into powder, and will keep in ordinary paper packages. It can also be compressed into hard cakes.

Four to five ounces of the dry powder represents one pound of meat. Scattered upon bread, its flavor is excellent and preferable to that of raw meat. It has an agreeable aromatic odor. And, as all of the albumen and fibrin are present, all of the nutritious properties of the flesh are retained.”.

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This methodology http://blog.lumitone.com/?p=48 report details the procedures and protocols followed to ensure the New Zealand Health Survey produces the high-quality and robust data how much does renova cream cost expected of official statistics.Included is information about. the survey population and sample design data collection where to buy renova online response rates and coverage rates weighting data processing analysis methods correction of errors in previously published data. Information specific to the data collection and analysis of the New Zealand Health Survey 2019/20 is included in Section 9 of this report..

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NIH research could lead to new treatment strategies for stomach cancer Glucocorticoids renova spa riu palace peninsula and androgens promote a healthy stomach pit by inhibiting inflammation, left, while their absence promotes inflammation http://bricksource.se/order-zithromax/ and SPEM seen in a diseased pit, right. SPEM glands are also much larger than healthy stomach glands. (Photo courtesy of Jonathan Busada, Ph.D./NIEHS) renova spa riu palace peninsula Scientists at the National Institutes of Health determined that stomach inflammation is regulated differently in male and female mice after finding that androgens, or male sex hormones, play a critical role in preventing inflammation in the stomach. The finding suggests that physicians could consider treating male patients with stomach inflammation differently than female patients with the same condition. The study was published in Gastroenterology.Researchers at NIH’s National Institute of Environmental Health Sciences (NIEHS) renova spa riu palace peninsula made the discovery after removing adrenal glands from mice of both sexes.

Adrenal glands produce glucocorticoids, hormones that have several functions, one of them being suppressing inflammation. With no glucocorticoids, the female renova spa riu palace peninsula mice soon developed stomach inflammation. The males did not. However, after removing androgens from the males, they exhibited the same stomach inflammation seen in the females."The fact that androgens are regulating inflammation is a novel idea," said co-corresponding author John Cidlowski, Ph.D., deputy chief of the NIEHS Laboratory of Signal renova spa riu palace peninsula Transduction and head of the Molecular Endocrinology Group. "Along with glucocorticoids, androgens offer a new way to control immune function in humans."While this study provides insight into how inflammation is being regulated in males, Cidlowski said additional research is underway to understand the process in females.

The scientist handling this phase of research is co-corresponding author Jonathan Busada, Ph.D., assistant professor at West Virginia renova spa riu palace peninsula University School of Medicine in Morgantown. When Busada started the project several years ago, he was a postdoctoral fellow working in Cidlowski’s group.Whether inflammation is inside the stomach or elsewhere in the body, Busada said rates of chronic inflammatory and autoimmune diseases vary depending on sex. He said eight out of 10 individuals with autoimmune disease are women, and his long-term goal is to figure out how glucocorticoids and androgens affect stomach cancer, which is induced by chronic inflammation.The current research focused on stomach glands called pits, which are embedded in the lining of the stomach.Busada said the renova spa riu palace peninsula study showed that glucocorticoids and androgens act like brake pedals on the immune system and are essential for regulating stomach inflammation. In his analogy, glucocorticoids are the primary brakes and androgens are the emergency brakes."Females only have one layer of protection, so if you remove glucocorticoids, they develop stomach inflammation and a pre-cancerous condition in the stomach called spasmolytic polypeptide-expressing metaplasia (SPEM)," Busada said. "Males have redundancy built renova spa riu palace peninsula in, so if something cuts the glucocorticoid brake line, it is okay, because the androgens can pick up the slack."The research also offered a possible mechanism — or biological process — behind this phenomenon.

In healthy stomach glands, the presence of glucocorticoids and androgens inhibit special immune cells called type 2 innate lymphoid cells (ILC2s). But in diseased stomach glands, the hormones renova spa riu palace peninsula are missing. As a result, ILC2s may act like a fire alarm, directing other immune cells called macrophages to promote inflammation and damage gastric glands leading to SPEM and ultimately cancer."ILC2s are the only immune cells that contain androgen receptors and could be a potential therapeutic target," Cidlowski said.This press release describes a basic research finding. Basic research increases our understanding of human behavior and biology, which is foundational to advancing renova spa riu palace peninsula new and better ways to prevent, diagnose, and treat disease. Science is an unpredictable and incremental process — each research advance builds on past discoveries, often in unexpected ways.

Most clinical advances would renova spa riu palace peninsula not be possible without the knowledge of fundamental basic research. To learn more about basic research, visit Basic Research – Digital Media Kit.Grant Numbers:ZIAES090057Fi2GM123974P20GM103434P20GM121322U54GM104942P30GM103488 Reference. Busada JT, Peterson KN, Khadka S, Xu, X, Oakley renova spa riu palace peninsula RH, Cook DN, Cidlowski JA. 2021. Glucocorticoids and androgens protect from gastric metaplasia by suppressing group 2 innate lymphoid cell activation.

Gastroenterology. Doi. 10.1053/j.gastro.2021.04.075 [Online 7 May 2021].CORVALLIS, Ore. €“ A team of Oregon State University scientists has discovered a new class of anti-cancer compounds that effectively kill liver and breast cancer cells. The findings, recently published in the journal Apoptosis, describe the discovery and characterization of compounds, designated as Select Modulators of AhR-regulated Transcription (SMAhRTs).

Edmond Francis O’Donnell III and a team of OSU researchers conducted the research in the laboratory of Siva Kolluri, a professor of cancer research at Oregon State. They also identified the aryl hydrocarbon receptor (AhR) as a new molecular target for development of cancer therapeutics. €œOur research identified a therapeutic lead that acts through a new molecular target for treatment of certain cancers,” Kolluri said. O’Donnell added. €œThis is an exciting development which lays a foundation for a new class of anti-cancer therapeutics acting through the AhR.” The researchers employed two molecular screening techniques to discover potential SMAhRTs and identified a molecule – known as CGS-15943 – that activates AhR signaling and kills liver and breast cancer cells.

Specifically, they studied cells from human hepatocellular carcinoma, a common type of liver cancer, and cells from triple negative breast cancer, which account for about 15% of breast cancers with the worst prognosis. €œWe focused on these two types of cancers because they are difficult to treat and have limited treatment options,” said Kolluri, a professor in the Department of Environmental and Molecular Toxicology in the College of Agricultural Sciences. €œWe were encouraged by the results because they are unrelated cancers and targeting the AhR was effective in inducing death of both of these distinct cancers.” The researchers also identified the AhR-mediated pathways that contribute to the anti-cancer actions of CGS-15943. Developing cancer treatments requires a detailed understanding of how they act to induce anti-cancer effects. The researchers determined that CGS-15943 increases the expression of a protein called Fas Ligand through the AhR and causes cancer cell death.

These results provide exciting new leads for drug development, but human therapies based on these results may not be available to patients for 10 years, the researchers said. An editorial commemorating the 25th anniversary issue of the journal Apoptosis highlighted this discovery and the detailed investigation of cancer cell death promoted by CGS-15943. In addition to Kolluri and O’Donnell, who recently completed medical school and is an orthopaedic surgery resident at UC Davis Medical Center, other authors of the paper are. Hyo Sang Jang and Nancy Kerkvliet, both from Oregon State. And Daniel Liefwalker, who formerly worked in Kolluri’s lab and is now at Oregon Health and Science University.

Kolluri is also part of Oregon State’s Linus Pauling Institute and The Pacific Northwest Center for Translational Environmental Health Research. Funding for the research came from the American Cancer Society, National Institute of Environmental Health Sciences, the U.S. Army Medical Research and Material Command, the Department of Defense Breast Cancer Research Program, Oregon State University and the National Cancer Institute..

NIH research could lead to http://bricksource.se/order-zithromax/ new treatment strategies for stomach cancer Glucocorticoids and androgens promote a healthy stomach how much does renova cream cost pit by inhibiting inflammation, left, while their absence promotes inflammation and SPEM seen in a diseased pit, right. SPEM glands are also much larger than healthy stomach glands. (Photo courtesy of Jonathan Busada, Ph.D./NIEHS) Scientists at the National how much does renova cream cost Institutes of Health determined that stomach inflammation is regulated differently in male and female mice after finding that androgens, or male sex hormones, play a critical role in preventing inflammation in the stomach.

The finding suggests that physicians could consider treating male patients with stomach inflammation differently than female patients with the same condition. The study was published in Gastroenterology.Researchers at NIH’s National Institute of Environmental Health Sciences (NIEHS) made the discovery after removing adrenal glands from how much does renova cream cost mice of both sexes. Adrenal glands produce glucocorticoids, hormones that have several functions, one of them being suppressing inflammation.

With no glucocorticoids, the female mice soon how much does renova cream cost developed stomach inflammation. The males did not. However, after removing androgens from the males, they exhibited the same stomach inflammation seen in the females."The fact that androgens are regulating inflammation is a novel idea," said co-corresponding author John Cidlowski, Ph.D., deputy chief of the NIEHS how much does renova cream cost Laboratory of Signal Transduction and head of the Molecular Endocrinology Group.

"Along with glucocorticoids, androgens offer a new way to control immune function in humans."While this study provides insight into how inflammation is being regulated in males, Cidlowski said additional research is underway to understand the process in females. The scientist handling this how much does renova cream cost phase of research is co-corresponding author Jonathan Busada, Ph.D., assistant professor at West Virginia University School of Medicine in Morgantown. When Busada started the project several years ago, he was a postdoctoral fellow working in Cidlowski’s group.Whether inflammation is inside the stomach or elsewhere in the body, Busada said rates of chronic inflammatory and autoimmune diseases vary depending on sex.

He said eight out of 10 individuals with autoimmune disease are women, and his how much does renova cream cost long-term goal is to figure out how glucocorticoids and androgens affect stomach cancer, which is induced by chronic inflammation.The current research focused on stomach glands called pits, which are embedded in the lining of the stomach.Busada said the study showed that glucocorticoids and androgens act like brake pedals on the immune system and are essential for regulating stomach inflammation. In his analogy, glucocorticoids are the primary brakes and androgens are the emergency brakes."Females only have one layer of protection, so if you remove glucocorticoids, they develop stomach inflammation and a pre-cancerous condition in the stomach called spasmolytic polypeptide-expressing metaplasia (SPEM)," Busada said. "Males have redundancy built in, so if something cuts the glucocorticoid brake line, it is okay, because the how much does renova cream cost androgens can pick up the slack."The research also offered a possible mechanism — or biological process — behind this phenomenon.

In healthy stomach glands, the presence of glucocorticoids and androgens inhibit special immune cells called type 2 innate lymphoid cells (ILC2s). But in diseased stomach glands, the how much does renova cream cost hormones are missing. As a result, ILC2s may act like a fire alarm, directing other immune cells called macrophages to promote inflammation and damage gastric glands leading to SPEM and ultimately cancer."ILC2s are the only immune cells that contain androgen receptors and could be a potential therapeutic target," Cidlowski said.This press release describes a basic research finding.

Basic research increases our understanding of human behavior and biology, which is foundational how much does renova cream cost to advancing new and better ways to prevent, diagnose, and treat disease. Science is an unpredictable and incremental process — each research advance builds on past discoveries, often in unexpected ways. Most clinical advances how much does renova cream cost would not be possible without the knowledge of fundamental basic research.

To learn more about basic research, visit Basic Research – Digital Media Kit.Grant Numbers:ZIAES090057Fi2GM123974P20GM103434P20GM121322U54GM104942P30GM103488 Reference. Busada JT, Peterson KN, Khadka S, Xu, X, Oakley RH, Cook DN, Cidlowski how much does renova cream cost JA. 2021.

Glucocorticoids and androgens protect from gastric metaplasia by suppressing group 2 innate lymphoid cell activation. Gastroenterology. Doi.

10.1053/j.gastro.2021.04.075 [Online 7 May 2021].CORVALLIS, Ore. €“ A team of Oregon State University scientists has discovered a new class of anti-cancer compounds that effectively kill liver and breast cancer cells. The findings, recently published in the journal Apoptosis, describe the discovery and characterization of compounds, designated as Select Modulators of AhR-regulated Transcription (SMAhRTs).

Edmond Francis O’Donnell III and a team of OSU researchers conducted the research in the laboratory of Siva Kolluri, a professor of cancer research at Oregon State. They also identified the aryl hydrocarbon receptor (AhR) as a new molecular target for development of cancer therapeutics. €œOur research identified a therapeutic lead that acts through a new molecular target for treatment of certain cancers,” Kolluri said.

O’Donnell added. €œThis is an exciting development which lays a foundation for a new class of anti-cancer therapeutics acting through the AhR.” The researchers employed two molecular screening techniques to discover potential SMAhRTs and identified a molecule – known as CGS-15943 – that activates AhR signaling and kills liver and breast cancer cells. Specifically, they studied cells from human hepatocellular carcinoma, a common type of liver cancer, and cells from triple negative breast cancer, which account for about 15% of breast cancers with the worst prognosis.

€œWe focused on these two types of cancers because they are difficult to treat and have limited treatment options,” said Kolluri, a professor in the Department of Environmental and Molecular Toxicology in the College of Agricultural Sciences. €œWe were encouraged by the results because they are unrelated cancers and targeting the AhR was effective in inducing death of both of these distinct cancers.” The researchers also identified the AhR-mediated pathways that contribute to the anti-cancer actions of CGS-15943. Developing cancer treatments requires a detailed understanding of how they act to induce anti-cancer effects.

The researchers determined that CGS-15943 increases the expression of a protein called Fas Ligand through the AhR and causes cancer cell death. These results provide exciting new leads for drug development, but human therapies based on these results may not be available to patients for 10 years, the researchers said. An editorial commemorating the 25th anniversary issue of the journal Apoptosis highlighted this discovery and the detailed investigation of cancer cell death promoted by CGS-15943.

In addition to Kolluri and O’Donnell, who recently completed medical school and is an orthopaedic surgery resident at UC Davis Medical Center, other authors of the paper are. Hyo Sang Jang and Nancy Kerkvliet, both from Oregon State. And Daniel Liefwalker, who formerly worked in Kolluri’s lab and is now at Oregon Health and Science University.

Kolluri is also part of Oregon State’s Linus Pauling Institute and The Pacific Northwest Center for Translational Environmental Health Research. Funding for the research came from the American Cancer Society, National Institute of Environmental Health Sciences, the U.S. Army Medical Research and Material Command, the Department of Defense Breast Cancer Research Program, Oregon State University and the National Cancer Institute..

Papier toilette couleur renova

NIH scientists say the papier toilette couleur renova approach may be a novel way to treat pneumonia in humans. The image shows S. Pneumoniae bacteria, shown in green, that have been engulfed by a macrophage papier toilette couleur renova from a wild-type mouse. (Photo courtesy of Hong Li, Ph.D.

/ NIEHS) Researchers papier toilette couleur renova at the National Institutes of Health have discovered a therapy that targets host cells rather than bacterial cells in treating bacterial pneumonia in rodents. The method involves white blood cells of the immune system called macrophages that eat bacteria, and a group of compounds that are naturally produced in mice and humans called epoxyeicosatrienoic acids or EETs. The research was published in the Journal of Clinical Investigation.According to the World Health Organization, pneumonia caused by Streptococcus papier toilette couleur renova pneumoniae, or pneumococcal pneumonia, is the leading cause of pneumonia deaths worldwide each year. While physicians usually prescribe antibiotics to treat this severe lung , treatment is not always successful, and in some cases, the bacteria become resistant.Matthew Edin, Ph.D., a scientist at the National Institute of Environmental Health Sciences (NIEHS), part of NIH, wanted to find a way to augment the body’s immune system to resolve the .To keep tissues healthy, EETs work to limit inflammation, but during s caused by S.

Pneumoniae and other microorganisms, inflammation ramps up papier toilette couleur renova after lung cells induce certain substances that prompt macrophages to gobble up the bacteria. Edin and colleagues found that one way to get macrophages to eat more bacteria is to decrease the ability of EETs to do what they normally do, which is limit inflammation.Edin led the team that found induces a protein called soluble epoxide hydrolase (sEH) that degrades EETs. In contrast, when sEH is blocked, EET levels skyrocket, hampering the macrophages’ ability to sense and eat bacteria. As a result, the bacteria continue to papier toilette couleur renova reproduce in the lung, which leads to severe lung and death.At the other end of the spectrum, blocking EETs using a synthetic molecule called EEZE boosted the eating capacity of the macrophages, leading to reduced numbers of bacteria in the lungs of mice.

The scientists saw the same result when they placed bacteria and macrophages harvested from lung and blood samples of human volunteers in test tubes at the NIEHS Clinical Research Unit.“EEZE is safe and effective in mice, but scientists could develop similar compounds to give to humans,” said Edin, who is co-lead author of the paper. €œThese new papier toilette couleur renova molecules could be used in an inhaler or pill to promote bacterial killing and make the antibiotics more effective.”NIEHS Scientific Director Darryl Zeldin, M.D., corresponding author of the research, has spent several years studying EETs and their impact on the human body. He and his research group determined that EETs provide beneficial cardiovascular effects, such as lowering blood pressure and inflammation, and improving cell survival after a stroke or heart attack. He stressed, however, that the involvement of EETs in the process of inflammation can be good or bad depending on the context.“EETs can suppress the inflammatory response, which is good, but if they block it too much, they’re going to make it so the macrophages can’t eat the bacteria, which is bad,” said Zeldin.Edin added that some researchers have tested sEH inhibitors — compounds that prevent sEH from degrading EETs — in clinical trials to see if they could help with pain, chronic papier toilette couleur renova obstructive pulmonary disease, and high blood pressure.

He cautioned that the scientists performing these studies consider the influence of sEH inhibitors on bacterial clearance.“They should be careful and stop using them if the individual develops pneumonia,” said Edin. €œOur study demonstrated that blocking sEH means EETs may hamstring macrophages, making a lung worse.”Co-author Stavros Garantziotis, M.D., papier toilette couleur renova medical director of the NIEHS Clinical Research Unit, was instrumental in collecting human macrophages for the research.“Since our study utilized lung immune cells from healthy volunteers, we have confidence that our findings are relevant to human health,” said Garantziotis.Grant Number. Z01ES025034Reference. Li H, Bradbury JA, Edin ML, Graves JP, Gruzdev A, Cheng J, Hoopes SL, DeGraff LM, Fessler MB, Garantziotis S, Schurman SH, Zeldin DC.

2021. SEH promotes macrophage phagocytosis and lung clearance of Streptococcus pneumoniae. J Clin Invest. Doi.

10.1172/JCI129679 [Online 30 September 2021]. [Abstract Li H, Bradbury JA, Edin ML, Graves JP, Gruzdev A, Cheng J, Hoopes SL, DeGraff LM, Fessler MB, Garantziotis S, Schurman SH, Zeldin DC. 2021. SEH promotes macrophage phagocytosis and lung clearance of Streptococcus pneumoniae.

J Clin Invest. Doi. 10.1172/JCI129679 [Online 30 September 2021].]News ReleaseTuesday, October 26, 2021New program will establish data science research and training network across the continent. The National Institutes of Health is investing about $74.5 million over five years to advance data science, catalyze innovation and spur health discoveries across Africa.

Under its new Harnessing Data Science for Health Discovery and Innovation in Africa (DS-I Africa) program, the NIH is issuing 19 awards to support research and training activities. DS-I Africa is an NIH Common Fund program that is supported by the Office of the Director and 11 NIH Institutes, Centers and Offices. Awards will establish a consortium consisting of a data science platform and coordinating center, seven research hubs, seven data science research training programs and four projects focused on studying the ethical, legal and social implications of data science research. Awardees have a robust network of partnerships across the African continent and in the United States, including numerous national health ministries, nongovernmental organizations, corporations, and other academic institutions.

€œThis initiative has generated tremendous enthusiasm in all sectors of Africa’s biomedical research community,” said NIH Director Francis S. Collins, M.D., Ph.D. €œBig data and artificial intelligence have the potential to transform the conduct of research across the continent, while investing in research training will help to support Africa’s future data science leaders and ensure sustainable progress in this promising field.” The University of Cape Town (UCT) will develop and manage the initiative’s open data science platform and coordinating center, building on previous NIH investments in UCT’s data and informatics capabilities made through the Human Heredity and Health in Africa (H3Africa) program. UCT will provide a flexible, scalable platform for the DS-I Africa researchers, so they can find and access data, select tools and workflows, and run analyses through collaborative workspaces.

UCT will also administer and support core resources, as well as coordinate consortium activities. The research hubs, all of which are led by African institutions, will apply novel approaches to data analysis and AI to address critical health issues including. Scientists in Kenya will leverage large, existing data sets to develop and validate AI models to identify women at risk for poor pregnancy outcomes. And to identify adolescents and young healthcare workers at risk of depression and suicide ideation.

A hub in Nigeria will study skin care and HIV with the goal of using data to improve renova preparedness. In Uganda, researchers will advance data science for medical imaging with efforts to improve diagnoses of eye disease and cervical cancer. Scientists in Nigeria will also study anti-microbial resistance and the dynamics of disease transmission, develop a portable screening tool for bacterial s and test a potential anti-microbial compound. A project based in Cameroon will investigate ways to decrease the burden of injuries and surgical diseases, as well as improve access to quality surgical care across the continent.

From a hub in South Africa, researchers will study multi-disease morbidity by analyzing clinical and genomic data with the goal of providing actionable insights to reduce disease burden and improve overall health. A project in South Africa will develop innovative solutions to mitigate the health impacts of climate change throughout the region, with initial studies of clinical outcomes of heat exposure on pregnant women, newborns and people living in urban areas.The research training programs, which leverage partnerships with U.S. Institutions, will create multi-tiered curricula to build skills in foundational health data science, with options ranging from master’s and doctoral degree tracks, to postdoctoral training and faculty development. A mix of in-person and remote training will be offered to build skills in multi-disciplinary topics such as applied mathematics, biostatistics, epidemiology, clinical informatics, analytics, computational omics, biomedical imaging, machine intelligence, computational paradigms, computer science and engineering.

Trainees will receive intensive mentoring and participate in practical internships to learn how to apply data science concepts to medical and public health areas including the social determinants of health, climate change, food systems, infectious diseases, noncommunicable diseases, health surveillance, injuries, pediatrics and parasitology. Recognizing that data science research may uncover potential ethical, legal and social implications (ELSI), the consortium will include dedicated ELSI research addressing these topics. This will include efforts to develop evidence-based, context specific guidance for the conduct and governance of data science initiatives. Evaluate current legal instruments and guidelines to develop new and innovative governance frameworks to support data science health research in Africa.

Explore legal differences across regions of the continent in the use of data science for health discovery and innovation. And investigate public perceptions and attitudes regarding the use of data science approaches for healthcare along with the roles and responsibilities of different stakeholder groups regarding intellectual property, patents, and commercial use of genomics data in health. In addition, the ELSI research teams will be embedded in the research hubs to provide important and timely guidance. A second phase of the program is being planned to encourage more researchers to join the consortium, foster the formation of new partnerships and address additional capacity building needs.

Through the combined efforts of all its initiatives, DS-I Africa is intended to use data science to develop solutions to the continent’s most pressing public health problems through a robust ecosystem of new partners from academic, government and private sectors. In addition to the Common Fund (CF), the DS-I Africa awards are being supported by the Fogarty International Center (FIC), the National Cancer Institute (NCI), the National Human Genome Research Institute (NHGRI), the National Institute of Allergy and Infectious Diseases (NIAID), the National Institute of Biomedical Imaging and Bioengineering (NIBIB), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Institute of Dental and Craniofacial Research (NIDCR), the National Institute of Environmental Health Sciences (NIEHS), the National Institute of Mental Health (NIMH), the National Library of Medicine (NLM) and the NIH Office of Data Science Strategy (ODSS). The initiative is being led by the CF, FIC, NIBIB, NIMH and NLM. More information is available at https://commonfund.nih.gov/AfricaData.

Photos depicting data science activities at awardee institutions are available for downloading at https://commonfund.nih.gov/africadata/images. About the NIH Common Fund. The NIH Common Fund encourages collaboration and supports a series of exceptionally high-impact, trans-NIH programs. Common Fund programs are managed by the Office of Strategic Coordination in the Division of Program Coordination, Planning, and Strategic Initiatives in the NIH Office of the Director in partnership with the NIH Institutes, Centers, and Offices.

More information is available at the Common Fund website. Https://commonfund.nih.gov.About the National Institutes of Health (NIH):NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases.

For more information about NIH and its programs, visit www.nih.gov. NIH…Turning Discovery Into Health®###.

NIH scientists say the approach may be a novel way to treat pneumonia Homepage in how much does renova cream cost humans. The image shows S. Pneumoniae bacteria, shown in green, that have been engulfed by a macrophage from how much does renova cream cost a wild-type mouse. (Photo courtesy of Hong Li, Ph.D. / NIEHS) Researchers at the National Institutes of how much does renova cream cost Health have discovered a therapy that targets host cells rather than bacterial cells in treating bacterial pneumonia in rodents.

The method involves white blood cells of the immune system called macrophages that eat bacteria, and a group of compounds that are naturally produced in mice and humans called epoxyeicosatrienoic acids or EETs. The research was published in the Journal of Clinical Investigation.According how much does renova cream cost to the World Health Organization, pneumonia caused by Streptococcus pneumoniae, or pneumococcal pneumonia, is the leading cause of pneumonia deaths worldwide each year. While physicians usually prescribe antibiotics to treat this severe lung , treatment is not always successful, and in some cases, the bacteria become resistant.Matthew Edin, Ph.D., a scientist at the National Institute of Environmental Health Sciences (NIEHS), part of NIH, wanted to find a way to augment the body’s immune system to resolve the .To keep tissues healthy, EETs work to limit inflammation, but during s caused by S. Pneumoniae and other microorganisms, inflammation ramps up after lung cells induce how much does renova cream cost certain substances that prompt macrophages to gobble up the bacteria. Edin and colleagues found that one way to get macrophages to eat more bacteria is to decrease the ability of EETs to do what they normally do, which is limit inflammation.Edin led the team that found induces a protein called soluble epoxide hydrolase (sEH) that degrades EETs.

In contrast, when sEH is blocked, EET levels skyrocket, hampering the macrophages’ ability to sense and eat bacteria. As a result, the bacteria continue to reproduce in the lung, which leads to severe lung and death.At the other end of how much does renova cream cost the spectrum, blocking EETs using a synthetic molecule called EEZE boosted the eating capacity of the macrophages, leading to reduced numbers of bacteria in the lungs of mice. The scientists saw the same result when they placed bacteria and macrophages harvested from lung and blood samples of human volunteers in test tubes at the NIEHS Clinical Research Unit.“EEZE is safe and effective in mice, but scientists could develop similar compounds to give to humans,” said Edin, who is co-lead author of the paper. €œThese new molecules could be used in an inhaler or pill to promote bacterial killing and make how much does renova cream cost the antibiotics more effective.”NIEHS Scientific Director Darryl Zeldin, M.D., corresponding author of the research, has spent several years studying EETs and their impact on the human body. He and his research group determined that EETs provide beneficial cardiovascular effects, such as lowering blood pressure and inflammation, and improving cell survival after a stroke or heart attack.

He stressed, how much does renova cream cost however, that the involvement of EETs in the process of inflammation can be good or bad depending on the context.“EETs can suppress the inflammatory response, which is good, but if they block it too much, they’re going to make it so the macrophages can’t eat the bacteria, which is bad,” said Zeldin.Edin added that some researchers have tested sEH inhibitors — compounds that prevent sEH from degrading EETs — in clinical trials to see if they could help with pain, chronic obstructive pulmonary disease, and high blood pressure. He cautioned that the scientists performing these studies consider the influence of sEH inhibitors on bacterial clearance.“They should be careful and stop using them if the individual develops pneumonia,” said Edin. €œOur study demonstrated that blocking sEH means EETs may hamstring macrophages, making a lung worse.”Co-author Stavros Garantziotis, M.D., medical director of the NIEHS Clinical Research Unit, was instrumental in collecting human macrophages for the research.“Since our study utilized lung immune cells from healthy volunteers, we have confidence that our findings are relevant how much does renova cream cost to human health,” said Garantziotis.Grant Number. Z01ES025034Reference. Li H, Bradbury JA, Edin ML, Graves JP, Gruzdev A, Cheng J, Hoopes SL, DeGraff LM, Fessler MB, Garantziotis S, Schurman SH, Zeldin DC.

2021. SEH promotes macrophage phagocytosis and lung clearance of Streptococcus pneumoniae. J Clin Invest. Doi. 10.1172/JCI129679 [Online 30 September 2021].

[Abstract Li H, Bradbury JA, Edin ML, Graves JP, Gruzdev A, Cheng J, Hoopes SL, DeGraff LM, Fessler MB, Garantziotis S, Schurman SH, Zeldin DC. 2021. SEH promotes macrophage phagocytosis and lung clearance of Streptococcus pneumoniae. J Clin Invest. Doi.

10.1172/JCI129679 [Online 30 September 2021].]News ReleaseTuesday, October 26, 2021New program will establish data science research and training network across the continent. The National Institutes of Health is investing about $74.5 million over five years to advance data science, catalyze innovation and spur health discoveries across Africa. Under its new Harnessing Data Science for Health Discovery and Innovation in Africa (DS-I Africa) program, the NIH is issuing 19 awards to support research and training activities. DS-I Africa is an NIH Common Fund program that is supported by the Office of the Director and 11 NIH Institutes, Centers and Offices. Awards will establish a consortium consisting of a data science platform and coordinating center, seven research hubs, seven data science research training programs and four projects focused on studying the ethical, legal and social implications of data science research.

Awardees have a robust network of partnerships across the African continent and in the United States, including numerous national health ministries, nongovernmental organizations, corporations, and other academic institutions. €œThis initiative has generated tremendous enthusiasm in all sectors of Africa’s biomedical research community,” said NIH Director Francis S. Collins, M.D., check my site Ph.D. €œBig data and artificial intelligence have the potential to transform the conduct of research across the continent, while investing in research training will help to support Africa’s future data science leaders and ensure sustainable progress in this promising field.” The University of Cape Town (UCT) will develop and manage the initiative’s open data science platform and coordinating center, building on previous NIH investments in UCT’s data and informatics capabilities made through the Human Heredity and Health in Africa (H3Africa) program. UCT will provide a flexible, scalable platform for the DS-I Africa researchers, so they can find and access data, select tools and workflows, and run analyses through collaborative workspaces.

UCT will also administer and support core resources, as well as coordinate consortium activities. The research hubs, all of which are led by African institutions, will apply novel approaches to data analysis and AI to address critical health issues including. Scientists in Kenya will leverage large, existing data sets to develop and validate AI models to identify women at risk for poor pregnancy outcomes. And to identify adolescents and young healthcare workers at risk of depression and suicide ideation. A hub in Nigeria will study skin care and HIV with the goal of using data to improve renova preparedness.

In Uganda, researchers will advance data science for medical imaging with efforts to improve diagnoses of eye disease and cervical cancer. Scientists in Nigeria will also study anti-microbial resistance and the dynamics of disease transmission, develop a portable screening tool for bacterial s and test a potential anti-microbial compound. A project based in Cameroon will investigate ways to decrease the burden of injuries and surgical diseases, as well as improve access to quality surgical care across the continent. From a hub in South Africa, researchers will study multi-disease morbidity by analyzing clinical and genomic data with the goal of providing actionable insights to reduce disease burden and improve overall health. A project in South Africa will develop innovative solutions to mitigate the health impacts of climate change throughout the region, with initial studies of clinical outcomes of heat exposure on pregnant women, newborns and people living in urban areas.The research training programs, which leverage partnerships with U.S.

Institutions, will create multi-tiered curricula to build skills in foundational health data science, with options ranging from master’s and doctoral degree tracks, to postdoctoral training and faculty development. A mix of in-person and remote training will be offered to build skills in multi-disciplinary topics such as applied mathematics, biostatistics, epidemiology, clinical informatics, analytics, computational omics, biomedical imaging, machine intelligence, computational paradigms, computer science and engineering. Trainees will receive intensive mentoring and participate in practical internships to learn how to apply data science concepts to medical and public health areas including the social determinants of health, climate change, food systems, infectious diseases, noncommunicable diseases, health surveillance, injuries, pediatrics and parasitology. Recognizing that data science research may uncover potential ethical, legal and social implications (ELSI), the consortium will include dedicated ELSI research addressing these topics. This will include efforts to develop evidence-based, context specific guidance for the conduct and governance of data science initiatives.

Evaluate current legal instruments and guidelines to develop new and innovative governance frameworks to support data science health research in Africa. Explore legal differences across regions of the continent in the use of data science for health discovery and innovation. And investigate public perceptions and attitudes regarding the use of data science approaches for healthcare along with the roles and responsibilities of different stakeholder groups regarding intellectual property, patents, and commercial use of genomics data in health. In addition, the ELSI research teams will be embedded in the research hubs to provide important and timely guidance. A second phase of the program is being planned to encourage more researchers to join the consortium, foster the formation of new partnerships and address additional capacity building needs.

Through the combined efforts of all its initiatives, DS-I Africa is intended to use data science to develop solutions to the continent’s most pressing public health problems through a robust ecosystem of new partners from academic, government and private sectors. In addition to the Common Fund (CF), the DS-I Africa awards are being supported by the Fogarty International Center (FIC), the National Cancer Institute (NCI), the National Human Genome Research Institute (NHGRI), the National Institute of Allergy and Infectious Diseases (NIAID), the National Institute of Biomedical Imaging and Bioengineering (NIBIB), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Institute of Dental and Craniofacial Research (NIDCR), the National Institute of Environmental Health Sciences (NIEHS), the National Institute of Mental Health (NIMH), the National Library of Medicine (NLM) and the NIH Office of Data Science Strategy (ODSS). The initiative is being led by the CF, FIC, NIBIB, NIMH and NLM. More information is available at https://commonfund.nih.gov/AfricaData. Photos depicting data science activities at awardee institutions are available for downloading at https://commonfund.nih.gov/africadata/images.

About the NIH Common Fund. The NIH Common Fund encourages collaboration and supports a series of exceptionally high-impact, trans-NIH programs. Common Fund programs are managed by the Office of Strategic Coordination in the Division of Program Coordination, Planning, and Strategic Initiatives in the NIH Office of the Director in partnership with the NIH Institutes, Centers, and Offices. More information is available at the Common Fund website. Https://commonfund.nih.gov.About the National Institutes of Health (NIH):NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S.

Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov. NIH…Turning Discovery Into Health®###.

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Jibo was bmw tilburg renova named the 2017 Product of the Year by Time Magazine. Revis also served in leadership roles at Nuance Communications where he helped build the company's healthcare strategy through a mix of product innovation, M&A, and strategic partnership development."Matt's experience driving healthcare strategy and growth through product innovation and strategic partnerships will no doubt help further our global mission of healthcare improvement," said Dan Burton, CEO of Health Catalyst. "We are grateful for his leadership and dedication to Twistle by Health Catalyst and are excited to have him as member of our world class leadership team."About Health CatalystHealth Catalyst is a leading provider of data and analytics bmw tilburg renova technology and services to healthcare organizations committed to being the catalyst for massive, measurable, data-informed healthcare improvement. Its customers leverage the cloud-based data platform—powered by data from more than 100 million patient records and encompassing trillions of facts—as well as its analytics software and professional services expertise to make data-informed decisions and realize measurable clinical, financial, and operational improvements.

Health Catalyst envisions a future in which all healthcare decisions are data informed.Media Contact:Amanda Hundtamanda.hundt@healthcatalyst.com 575-491-0974 bmw tilburg renova View original content to download multimedia:https://www.prnewswire.com/news-releases/matt-revis-joins-health-catalyst-leadership-team-301364818.htmlSOURCE Health CatalystALBUQUERQUE, N.M. And SALT LAKE CITY, Aug. 24, 2021 bmw tilburg renova /PRNewswire/ -- Twistle by Health Catalyst, Inc. (Nasdaq.

HCAT) ("Twistle"), a leader in patient engagement technology, is now being used to support obstetric services bmw tilburg renova for patients in Northeastern New Mexico. Rural OB Access &. Maternal Services (ROAMS), a federally funded four-year grant from the Health Resources and Services Administration, has deployed Twistle across its network of care, which links patients to caregivers across five rural communities in New Mexico, including Taos, Colfax, Union, bmw tilburg renova Harding, and Mora Counties. "Our goal with ROAMS is to improve maternal access to care in a safe and financially viable model.

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This technology allows us to reach women wherever they are. We are aiming to improve access, reduce bmw tilburg renova long travel to clinics/specialty care and enhance detection of antepartum and postpartum problems. We know that early intervention prevents a lot of complications."Twistle's HIPAA-compliant, personalized text-based software supports pre- and post-partum patients with access to supportive messages such has detailed care plan information, educational materials, and reminders about appointments. In addition, the platform bmw tilburg renova can be used to collect assessments and enable providers to communicate with patients to monitor health and allow patients to request assistance.

As a result, conditions such as worsening gestational diabetes or hypertension during pregnancy and after delivery may be detected early and managed more safely with better provider-patient engagement."In our experience, we have been able to improve access and reduce health inequities by connecting patients to digital care and services and alleviating barriers like transportation issues, inflexible work schedules, and childcare challenges," said Twistle Medical Director Dr. Rameet Singh, MD, bmw tilburg renova MPH. "I am excited to play a role in this important women's health initiative not only through my role at Twistle but also as a practicing OB-GYN in New Mexico."Twistle's work with ROAMS highlights the value of patient engagement in improving the health of a population and underscores the opportunity for Twistle, together with data and analytics technology and services company Health Catalyst, to deliver massive, measurable, data-informed healthcare improvements.To learn more about ROAMS, visit https://roamsnm.org/. About Twistle bmw tilburg renova by Health CatalystTwistle helps care teams transform the patient experience, improve quality, and reduce costs through patient-centered, HIPAA-compliant communication.

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As we enter the next stage of our journey, it's my aim how much does renova cream cost to drive even greater care outcomes for our healthcare clients and their patients," said Revis. "I look forward to working with my fellow team members across the Health Catalyst organization to ensure Twistle reaches its full potential and delivers on our mission of massive, measurable healthcare improvement."Prior to joining Twistle in 2019, Revis served as a Head of Product at Jibo, where he was responsible for the full product development lifecycle of the world's first social robot for the home. Jibo was named the 2017 Product of the how much does renova cream cost Year by Time Magazine.

Revis also served in leadership roles at Nuance Communications where he helped build the company's healthcare strategy through a mix of product innovation, M&A, and strategic partnership development."Matt's experience driving healthcare strategy and growth through product innovation and strategic partnerships will no doubt help further our global mission of healthcare improvement," said Dan Burton, CEO of Health Catalyst. "We are grateful for his leadership and dedication to Twistle by Health Catalyst and are excited to have him as member of our world class leadership team."About Health CatalystHealth Catalyst is a leading provider of data and analytics technology and services to healthcare organizations committed to how much does renova cream cost being the catalyst for massive, measurable, data-informed healthcare improvement. Its customers leverage the cloud-based data platform—powered by data from more than 100 million patient records and encompassing trillions of facts—as well as its analytics software and professional services expertise to make data-informed decisions and realize measurable clinical, financial, and operational improvements.

Health Catalyst envisions a future in which all healthcare decisions are data informed.Media Contact:Amanda Hundtamanda.hundt@healthcatalyst.com 575-491-0974 View original content how much does renova cream cost to download multimedia:https://www.prnewswire.com/news-releases/matt-revis-joins-health-catalyst-leadership-team-301364818.htmlSOURCE Health CatalystALBUQUERQUE, N.M. And SALT LAKE CITY, Aug. 24, 2021 /PRNewswire/ -- Twistle how much does renova cream cost by Health Catalyst, Inc.

(Nasdaq. HCAT) ("Twistle"), a how much does renova cream cost leader in patient engagement technology, is now being used to support obstetric services for patients in Northeastern New Mexico. Rural OB Access &.

Maternal Services (ROAMS), a federally funded four-year grant from the Health Resources how much does renova cream cost and Services Administration, has deployed Twistle across its network of care, which links patients to caregivers across five rural communities in New Mexico, including Taos, Colfax, Union, Harding, and Mora Counties. "Our goal with ROAMS is to improve maternal access to care in a safe and financially viable model. We support mothers with holistic services, including education and care navigation, and make OB services for our rural how much does renova cream cost communities sustainable.

Preventing unnecessary travel, especially for specialty care, is key to the success of this program," said Dr. Timothy Brininger MD, FP/OB, Medical Director of ROAMS.Dr. Brininger continued, "With Twistle, we connect women directly to their care teams through their mobile phones or a tablet how much does renova cream cost.

This technology allows us to reach women wherever they are. We are aiming to improve access, reduce long travel to how much does renova cream cost clinics/specialty care and enhance detection of antepartum and postpartum problems. We know that early intervention prevents a lot of complications."Twistle's HIPAA-compliant, personalized text-based software supports pre- and post-partum patients with access to supportive messages such has detailed care plan information, educational materials, and reminders about appointments.

In addition, the platform can be how much does renova cream cost used to collect assessments and enable providers to communicate with patients to monitor health and allow patients to request assistance. As a result, conditions such as worsening gestational diabetes or hypertension during pregnancy and after delivery may be detected early and managed more safely with better provider-patient engagement."In our experience, we have been able to improve access and reduce health inequities by connecting patients to digital care and services and alleviating barriers like transportation issues, inflexible work schedules, and childcare challenges," said Twistle Medical Director Dr. Rameet Singh, MD, MPH how much does renova cream cost.

"I am excited to play a role in this important women's health initiative not only through my role at Twistle but also as a practicing OB-GYN in New Mexico."Twistle's work with ROAMS highlights the value of patient engagement in improving the health of a population and underscores the opportunity for Twistle, together with data and analytics technology and services company Health Catalyst, to deliver massive, measurable, data-informed healthcare improvements.To learn more about ROAMS, visit https://roamsnm.org/. About Twistle by Health CatalystTwistle helps care teams transform the patient experience, how much does renova cream cost improve quality, and reduce costs through patient-centered, HIPAA-compliant communication. We offer "turn-by-turn" guidance as patients navigate their health journey - before, during, and after a care episode.

A rich library of clinical content and best practices optimizes patient engagement to improve how much does renova cream cost care plan compliance. In addition, Twistle delivers education, coaching, remote patient monitoring, and assessment forms to regularly connect patients and care teams, delivering a more comprehensive patient experience that saves valuable staff time, improves patient satisfaction and clinical outcomes, decreases avoidable readmissions and ED visits, and reduces the length of stay.About Health CatalystHealth Catalyst is a leading provider of data and analytics technology and services to healthcare organizations committed to being the catalyst for massive, measurable, data-informed healthcare improvement. Its customers leverage the cloud-based data platform—powered by data from more than 100 million patient records and encompassing trillions of facts—as well as its analytics software and professional services expertise to make how much does renova cream cost data-informed decisions and realize measurable clinical, financial, and operational improvements.

Health Catalyst envisions a future in which all healthcare decisions are data informed.About Rural OB Access &. Maternal Services Project how much does renova cream cost (ROAMS)ROAMS, the Rural Ob Access &. Maternal Service, is a collaboration between Holy Cross Medical Center (HCMC) in Taos, Miner's Colfax Medical Center (MCMC) in Raton, Union County General Hospital (UCGH) in Clayton, Presbyterian Medical Services Questa Health Center (PMS/QHC), and the First Steps program in Taos.

Its goal is to improve maternal how much does renova cream cost health outcomes in Northeastern New Mexico. ROAMS is improving maternal access to care in the northeast region of New Mexico by setting up two new prenatal clinics, one at the Questa Health Center and the other at UCGH in Clayton. This will enable coordinated communication between how much does renova cream cost the four hospitals and clinics and will establish telehealth communication with expectant mothers from their own homes.

When fully functional it is expected that a patient will be able to engage with her OB providers as well as Maternal-Fetal medicine experts from their own home or their local hospital or clinic. View original content to download multimedia:https://www.prnewswire.com/news-releases/twistle-and-roams-partner-to-improve-access-to-prenatal-care-301361327.htmlSOURCE Twistle by Health Catalyst Amanda Hundt, amanda.hundt@healthcatalyst.com, 575-491-0974.

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AbstractIn ‘Chronic fatigue syndrome and how much does renova cream cost an http://www.ec-cath-bischheim.ac-strasbourg.fr/bienvenue-aux-ecoles-st-laurent/ illness-focused approach to care. Controversy, morality and paradox’, authors Michael Sharpe and Monica Greco begin by characterising myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) as illness-without-disease. On that basis they ask why patients reject treatments for illness-without-disease, and they answer with a philosophical idea.

Whitehead’s ‘bifurcation of nature’, they suggest, still dominates public and professional thinking, and that conceptual how much does renova cream cost confusion leads patients to reject the treatment they need. A great deal has occurred, however, since Whitehead characterised his culture’s confusions 100 years ago. In our time, I suggest, experience is no longer construed as an invalid second cousin of bodily states in philosophy, in medicine or in the culture at large.

More importantly, we must evaluate medical explanations before how much does renova cream cost we reach for philosophical alternatives. The National Institutes of Health and the Institute of Medicine have concluded that ME/CFS is, in fact, a biomedical disease, and all US governmental health organisations now agree. Although it would be productive for Sharpe and Greco to state and support their disagreement with the other side of the disease debate, it is no longer tenable, or safe, to ignore the possibility of disease in patients with ME/CFS, or to recommend that clinicians should do so.

When we find ourselves in a framework that suggests the possibility of medical need is somehow beside the point for medical providers, it is time to reconsider our conceptual foundations.medical humanitiespsychiatrymedical ethics/bioethicsphilosophy of medicine/health carehealth policy.